Rasburicase in the treatment of acute kidney injury in a boy with non-malignancy hyperuricemia

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Rasburicase in the treatment of acute kidney injury in a boy with non-malignancy hyperuricemia

In the manuscript authors describe the application of rasburicase in the treatment of acute kidney injury in a child with non-malignancy associated hyperuricemia and combined congenital abnormalities. Rasburicase application was safe, well tolerated and rapidly effective. The significant fall in serum uric acid levels was accompanied by rising diuresis. The improvement of renal function prevent...

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Rasburicase for acute kidney injury.

BACKGROUND Acute kidney injury (AKI) continues to have significant mortality and morbidity and the search is on for any novel therapeutic intervention. CASE CHARACTERISTICS Two cases of AKI with elevated SUA (serum uric acid). INTERVENTION Rasburicase. OUTCOME In Case 1 (late preterm male with AKI) rasburicase resulted in a significant reduction of SUA along with improvement in renal para...

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Single dose of rasburicase for treatment of hyperuricemia in acute kidney injury: a report of 3 cases.

Severe hyperuricemia accompanied by the other comorbidities such as anuria, fluid overload, calcium-phosphate imbalance, and/or tumor lysis syndrome is one of the indications for dialysis in the setting of acute kidney injury. Rasburicase is used in different clinical conditions such as tumor lysis syndrome and uric acid nephropathy. Among referred patients to our center from 2008 to 2010, ther...

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Reversal of Severe Volume Deplete Acute Kidney Injury by Rasburicase

We report on a case of acute kidney injury in a patient with severe volume depletion from high ileostomy output and poor oral intake associated with hyperuricemia and hyperkalemia. The patient presented with similar features on three separate admissions. A conservative management approach was undertaken that included infusion of rasburicase, since the patient refused to undergo hemodialysis on ...

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ژورنال

عنوان ژورنال: Pediatria Polska

سال: 2012

ISSN: 0031-3939

DOI: 10.1016/j.pepo.2012.06.001